The role of vitamin D deficiency and supplementation in onset and progression of diabetic nephropathy: A systematic review

  • Ahmad shamim Khan
  • Muhammed Zubair physcian at dubai health authourity
  • Shakeel Khan
  • Usman khalid
  • Khawar Sultan
  • Muhammad Kashif Khan
Keywords: Diabetic nephropathy, Vitamin D deficiency, Vitamin D3, Vitamin D analogues, prevention of progression

Abstract

Diabetes mellitus (DM) and chronic kidney disease (CKD) are linked to Vitamin D deficiency in the realm of diabetic nephropathy. Vitamin D3 and Vitamin D analogues are increasingly assessed to hinder the progression of diabetic nephropathy. Hence, vitamin D supplementation in combating the progression of diabetic nephropathy was focussed. Pathogenesis of diabetic nephropathy is associated with oxidative stress and inflammation, regulated by nuclear receptors such as vitamin D receptor (VDR). Thus inhibiting progression underlies the molecular mechanistic mode of receptor based changes. Comprehensive analysis for mitigation of progression of diabetic nephropathy upon Vitamin D enrichment reveals potentiating benefits for retarding progression.

Published
2022-03-28
How to Cite
Khan, Ahmad, Muhammed Zubair, Shakeel Khan, Usman khalid, Khawar Sultan, and Muhammad Kashif Khan. 2022. “The Role of Vitamin D Deficiency and Supplementation in Onset and Progression of Diabetic Nephropathy: A Systematic Review”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 29 (1), 135-54. https://rjdnmd.org/index.php/RJDNMD/article/view/1093.