Characteristics of certain genetical and biological properties of carcinogenesis in the development of inflammatory breast cancer with type 2 diabetes mellitus and tumor relapse

  • Michael Ivanovich Sheremet Surgery department of Bucovinian medical University
  • Bagmut Irina Yuriivna
  • Movchan Oleksii Volodimirovich
  • Smolanka Ivan Ivanovich
  • Lyashenko Andriy Oleksandrovich
  • Dosenko Irina Viktorivna
  • Loboda Anton Dmitrovich
  • Kolisnyk Igor Leonidovich
Keywords: inflammatory breast cancer, carcinogenesis pathways, the variability of the occurrence of factors of inflammatory breast cancer, type 2 diabetes mellitus.

Abstract

Introduction.  The aim of the work the ability to increase the effectiveness of comprehensive treatment of patients with inflammatory breast cancer with type 2 diabetes mellitus by individualization based on the determination of carcinogenesis indicators of the malignant process.

The aim of the study the ability to increase the effectiveness of comprehensive treatment of patients with inflammatory breast cancer with type 2 diabetes mellitus by individualization based on the determination of carcinogenesis indicators of the malignant process.

Materials and research methods. We examined 80 patients with Inflammatory breast cancer with type 2 diabetes mellitus, who were determined MSI at the loci of BAT 25; BAT 26, Ki-67 proliferation index, and p53 gene mutation and plasma glucose level control.  To assess the effectiveness of treatment depending on the biological properties of the tumor, in tumor tissue studied the expression levels of p53 protein, the index of proliferative activity of Ki-67, determined the presence of MSI at the loci BAT-25 and BAT-26 and their interconnection and dependence on each other.

Results.

It is established in this case; this is realized due to the inability of the mutant form of the p53 gene to synthesize the desired Quaternary configuration of the corresponding protein with the subsequent inability of the latter to stop the process of DNA replication. It was found that the proliferative activity of tumor cells in inflammatory breast cancer had a clear relationship with MSI at both studied chromosome loci. The presence of MSI is somehow associated with hyperglycosemia and is an aggravating factor in the course of inflammatory breast cancer with a poorer response to specific therapy.

Published
2022-06-23
How to Cite
Sheremet, Michael, Bagmut Yuriivna, Movchan Volodimirovich, Smolanka Ivanovich, Lyashenko Oleksandrovich, Dosenko Viktorivna, Loboda Dmitrovich, and Kolisnyk Leonidovich. 2022. “Characteristics of Certain Genetical and Biological Properties of Carcinogenesis in the Development of Inflammatory Breast Cancer With Type 2 Diabetes Mellitus and Tumor Relapse”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 29 (2), 245-52. https://rjdnmd.org/index.php/RJDNMD/article/view/1155.