Dyslipidemia as a predictor of essential arterial hypertension depending on AGTR1 (RS5186) and VDR (RS2228570) genes polymorphism
Background and aims: The purpose of the work was to study lipid disorders and essential arterial hypertension (EAH) risk depending on AGTR1 (rs5186), VDR (rs2228570) genes polymorphism. Material and method: 100 subjects with EAH and target-organ damaging (2nd stage), moderate, high or very high cardiovascular risk were involved in the case-control study. Control group consisted of 60 healthy individuals of relevant gender and age. Lipid panel was determined by colorimetric enzymatic method. Gene polymorphism of AGTR1 (rs5186) and VDR (rs2228570) was detected by polymerase chain reaction. Results: The EAH risk increases in C-allele carriers of AGTR1 (rs5186) gene at hypercholesterolemia 1.5 times, at an increase in low-density lipoprotein cholesterol (LDL-C) and atherogenic index (AI) – 1.58 and 2.12 times, respectively. Risk of EAH increases at hypertriglyceridemia 1.89 times and at increase in LDL-C – 1.26 times in AA-genotype carriers of VDR (rs2228570) gene. Risk of EAH synergistically escalates almost twice in A-allele carriers of VDR (rs2228570) gene with a decrease of high-density lipoprotein cholesterol (HDL-C) and increase of AI, significantly in AG-carriers, though. Conclusions: The EAH risk escalates at hypercholesterolemia, elevated LDL-C and AI in C-allele carriers of AGTR1 (rs5186) gene, likewise at decreased HDL-C, increased AI in A-allele carriers of VDR (rs2228570) gene in the observed.