Comparative analysis of the structure and the function of the pancreas in patients with a combination of chronic pancreatitis and metabolic syndrome
Abstract
In recent years, scientists are increasingly interested in the problem of influence of metabolic syndrome (MS) on gastrointestinal diseases. The aim of the study was to investigate the structure and the function of the pancreas in patients with a combination of chronic pancreatitis and metabolic syndrome. The higher BMI by 17.14%, waist circumference by 21.49%, WHR by 17.14%, WTR by 9.52%, WAR by 9.37%, WHtR by 30.00% have been found in patients with comorbid CBP and MS in comparison with the same in patients with isolated CBP (p<0.05).Among the patients with CBP, the liver stiffness index was (6.88±0.24) kPa and it was significantly higher by 30.2% than that in the control group (p<0.05). In patients with CBP+MS, the liver stiffness index was (7.70±0.15) kPa, which was higher by 37.6% and 10.6% than that in the control group and patients with CBP, respectively (p<0.05). The pancreas stiffness index was (7.08±0.11) kPa in patients with CBP and MS and it was higher by 34.0% and 8.6% compared to the same indexes in healthy people and those suffering from CBP, respectively (p<0.05). The concentration of fecal α-elastase 1 in patients with CBP+MS was (114.52±2.79) μg/g, which was significantly lower than the same in patients with CBP without MS (158.60±5.55) μg/g (p<0.05). The obtained results proved an aggravating effect of comorbid metabolic syndrome on the structure of the liver and on the structure and function of the pancreas in patients with chronic biliary pancreatitis.