Chondroitin sulfate in osteoarthritis management among diabetic patients: molecular mechanisms and clinical potential

  • Olexandr Kuryata Department of Internal Medicine 2, Phthisiology, Occupational Diseases and Clinical Immunology, Dnipro State Medical University, Dnipro, Ukraine
  • Oleh Akimov Department of Pathophysiology, Poltava State Medical University, Poltava, Ukraine
  • Sofiia Denisenko Department of Pathophysiology, Poltava State Medical University, Poltava, Ukraine
  • Heorhii Kostenko Department of Foreign Languages with Latin and Medical Terminology, Poltava State Medical University, Poltava, Ukraine
  • Viktoriia Kostenko Department of Foreign Languages with Latin and Medical Terminology, Poltava State Medical University, Poltava, Ukraine
  • Arthur Mishchenko Department of Pathophysiology, Poltava State Medical University, Poltava, Ukraine
  • Natalia Solovyova Department of Pathophysiology, Poltava State Medical University, Poltava, Ukraine
  • Vitalii Kostenko Department of Pathophysiology, Poltava State Medical University, Poltava, Ukraine
Keywords: osteoarthritis, type 2 diabetes mellitus, chronic low-grade systemic inflammation, standardized small marine fish extract, chondroitin sulfate

Abstract

Osteoarthritis and type 2 diabetes mellitus are two prevalent chronic conditions that impose a substantial burden on healthcare systems worldwide. The comorbidity of type 2 diabetes mellitus and osteoarthritis (especially in individuals with overweight/obesity) presents a formidable challenge due to the potential synergistic effects of these conditions on metabolism and joint health. Chronic low-grade systemic inflammation plays a pivotal role in the development of both type 2 diabetes mellitus and osteoarthritis and is a common feature they share. Chondroitin sulfate is a naturally occurring glycosaminoglycan integral to the structure and function of articular cartilage. It has gained attention as a potential therapeutic agent for osteoarthritis due to its multifaceted mechanisms of action, including an effect on transcriptional factors and signaling pathways associated with chronic low-grade systemic inflammation. Chondroitin sulfate originated from natural sources, including standardized small marine fish extract, and can be regarded as a promising means in the therapy of osteoarthritis and type 2 diabetes mellitus. It can serve as an illustrative medication able to alleviate NF-κB-mediated inflammatory and metabolic disorders. Standardized small marine fish extract demonstrates anti-inflammatory, antioxidant, antidiabetic, anti-cancer, antimicrobial, anti-hypertensive, and wound healing properties.

Published
2023-12-31
How to Cite
Kuryata, Olexandr, Oleh Akimov, Sofiia Denisenko, Heorhii Kostenko, Viktoriia Kostenko, Arthur Mishchenko, Natalia Solovyova, and Vitalii Kostenko. 2023. “Chondroitin Sulfate in Osteoarthritis Management Among Diabetic Patients: Molecular Mechanisms and Clinical Potential”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 30 (4), 481-93. https://rjdnmd.org/index.php/RJDNMD/article/view/1425.