SEX DIFFERENCES IN LOWER EXTREMITIES AMPUTATIONS IN PATIENTS WITH DIABETES - FIVE YEAR NATIONWIDE FOLLOW-UP USING DRG DATA IN ROMANIA
Background and Aims. The present study represents the first nationwide evaluation of lower extremities amputations (LEA) in diabetes patients in Romania. Material and Methods. We used the disease related groups (DRG) data provided by the National School for Public Health, Management and Health Education, for the years 2006-2010 and stratified according to diabetes type, sex and age group. Results. There were 16873 patients with diabetes who underwent a total number of 24312 non traumatic LEA. A total of 22.55% of the patients had type 1 diabetes (T1DM) and 70.26 % had type 2 diabetes (T2DM). The rate of amputations decreased in T1DM and increased in T2DM, especially in elderly people. Male-to-female ratio of amputations was ~2:1 in T1DM and ~2.4:1 in T2DM. The predictions for the number of amputation episodes was approximated by the regression line y=286.8x-572728 r=0.97, p=0.005, d=0.95 in men, and by y=91.1x- 181511, r=0.98, p=0.004, d=0.95 in women ( where x is years and y is number of amputation episodes). Conclusions. Identifying certain age and sex groups of patients with diabetes in whom higher increase of LEA rates are observed imposes a change of strategy concerning prevention and curative measures.