Androgen-secreting ovarian tumor complicated by secondary erythrocytosis in a postmenopausal women

Abstract

Androgen-secreting ovarian tumors are a rare pathology that occurs both in a woman’s reproductive period and in the postmenopausal period. We have described a rare clinical case of acute virilization growth in the postmenopausal woman. The diagnosis of the left ovary androgen-secreting tumor was made on the base of a significant increase in testosterone and 17-OH progesterone, suppression of gonadotropic hormones, and left ovary solid hypoechoic lesion obtained by ultrasound examination. The patient had concomitant pathologies: type 2 diabetes mellitus, arterial hypertension, and secondary erythrocytosis. After panhysterectomy with omentectomy, the patient experienced gradual regression of hirsutism and virilization. Laboratory examinations 6 months after the operation showed that testosterone and 17 OH progesterone levels were normalized, gonadotropin levels corresponded to the postmenopausal period and erythrocytosis was eliminated.