Survey of HOMA1-IR and HOMA2-IR indexes in first-diagnosed type 2 diabetes patients

Abstract

Insulin resistance is the primary pathogenesis leading to type 2 diabetes. The HOMA model is widely used to assess insulin resistance. This study aims to examine the HOMA1-IR and HOMA2-IR indices in patients with type 2 diabetes diagnosed for the first time. A comparative cross-sectional study including two groups: the patient group was patients with type 2 diabetes diagnosed for the first time (n=101), and the control group was healthy people (n=98). Statistical analysis was performed using SPSS 22.0 software. The study showed that patients with type 2 diabetes had an average value of HOMA1-IR of 3.79 and HOMA2-IR of 1.79, significantly higher than that of healthy people. With a cutoff value of 1.96, the sensitivity and specificity of HOMA1-IR to distinguish between disease and non-disease were 91.1% and 96.9%, respectively. For HOMA2-IR with a cutoff of 0.96, the sensitivity and specificity were 62.4% and 86.7%, respectively. Patients with type 2 diabetes diagnosed for the first time had higher HOMA1-IR and HOMA2-IR than healthy people; HOMA1-IR and HOMA2-IR were higher in type 2 diabetic patients with dyslipidemia than in type 2 diabetic patients without dyslipidemia. HOMA1-IR had higher sensitivity and specificity than HOMA2-IR in distinguishing type 2 diabetes from healthy people.