Analysis of urinary ET-1 levels and kidney function in obese and non-obese young adults

Wulandari Wulandari; Irfan Idris; Andi Ariyandy; Muhammad Aryadi Arsyad; Muhammad Husni Cangara

Wulandari Wulandari Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Irfan Idris Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Andi Ariyandy Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Muhammad Aryadi Arsyad Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Muhammad Husni Cangara Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

Keywords: obesity, endothelin-1, creatinine, urea, glomerular filtration rate

Abstract

Obesity is characterized by abnormal fat accumulation. The onset and morbidity of obesity are common in adults, leading to various complications, including decreased renal function. Endothelin-1, a molecule that functions as a vasoconstrictor, significantly contributes to the pathophysiology of the renal and cardiovascular systems. This cross-sectional analytical study used purposive sampling, involving 30 obese and 26 non-obese young adult subjects. Urine samples were analyzed using the human Endothelin-1 kit with the ELISA method, while blood samples were analyzed for urea and creatinine levels using an enzymatic technique. The results of urinary Endothelin-1 concentrations between the obese group, which had a median of 92.27 ng/L, and the non-obese group, with a median of 74.41 ng/L. Kidney function test showed in the group for urea 16.50 mg/dL, creatinine 0.70 mg/dL, and GFR 128.35 ml/min/1.73 m2, while the non-obese group showed urea 22.00 mg/dL, creatinine 0.65 mg/dL, and GFR 148.97 ml/min/1.73 m2. The levels of Urinary Endothelin-1 were notably elevated in obese individuals compared to those who were not obese. However, kidney function, as measured by urea, creatinine, and GFR, was not consistently worse in the obese group.