Determinants of hyperhomocysteinemia in sports pratice among individuals with type 2 diabetes in Cote d’Ivoire

Jean Jacques Diagou; Adou Koffi Kunindjani; Audrey Herbert Yepié; Anin Louise Anin Atchibri; Félix Acka; Rebecca N’Guessan-Blao

Jean Jacques Diagou Laboratory of Nutrition and Food Safety, Faculty of Food Science and Technology, Nangui Abrogoua University, Abidjan, Côte d’Ivoire
Adou Koffi Kunindjani Departement of Nutrition, National Institute of Public Health of Abidjan, Abidjan, Côte d’Ivoire
Audrey Herbert Yepié Laboratory of Nutrition and Food Safety, Faculty of Food Science and Technology, Nangui Abrogoua University, Abidjan, Côte d’Ivoire
Anin Louise Anin Atchibri Laboratory of Nutrition and Food Safety, Faculty of Food Science and Technology, Nangui Abrogoua University, Abidjan, Côte d’Ivoire
Félix Acka Abidjan Antidiabetic Center (CADA), National Institute of Public Health of Abidjan, Abidjan, Côte d’Ivoire
Rebecca N’Guessan-Blao Laboratory of Research and Medical Biology, National Institute of Public Health (INSP) of Abidjan, Abidjan, Côte d’Ivoire

Keywords: homocysteine, hyperhomocysteinemia, physical activity, type 2 diabetes, Côte d’Ivoire

Abstract

Several studies have established a link between nutrition, physical activity, and hyperhomocysteinemia. High-intensity physical activity has been implicated as a risk factor for hyperhomocysteinemia. The objective of this study was to investigate the causes of increased homocysteine levels through physical activity in type 2 diabetics in Côte d’Ivoire. This was a descriptive cross-sectional study conducted on 181 volunteers type 2 diabetics, aged from 23 to 86 years, regularly monitored at the Abidjan Antidiabetic Center. They were submitted to the WHO Global Physical Activity Questionnaire. Homocysteine levels were measured using the enzymatic cycling method. The study revealed that the factors increasing homocysteine levels through physical activity in Ivorian type 2 diabetics were: high-intensity exercise (2.2%), particularly in males; moderate exercise equivalent to intense exercise in those over 70 years, due to the physiological decline in renal function associated with aging; the sedentary lifestyle (46.96%), particularly in those over 50 years of age; and age itself in relation to a sedentary lifestyle. Conversely, moderate exercise (50.83%) did not increase hyperhomocysteinemia, either across the 20–69 age group or according to normo- or hyperhomocysteinemic status. Moderate physical activity is protective against hyperhomocysteinemia. It can be recommended and prescribed for hyperhomocysteinemia prevention and treatment.