DYNAMICS OF PROSTATE-SPECIFIC ANTIGEN LEVELS DURING TREATMENT WITH TESTOSTERONE UNDECANOATE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

  • Rucsandra Dănciulescu Miulescu
  • Suzana Dănoiu
  • Denisa Margină
  • Sorin Păun
  • Cătălina Poiana
Keywords: prostate-specific antigen, diabetes mellitus, estosterone replacement therapy, risk factors

Abstract

Objectives. Prostate-specific antigen (PSA) is the most used and validated marker of prostate cancer risk. The aim of this study was to assess PSA levels during treatment with testosteronum undecanoat in patients with type 2 diabetes (T2DM). Material and Methods. We evaluated 38 T2DM patients aged between 48 and 61 years with confirmed hypogonadism. 1000 mg testosterone undecanoate was injected intramuscular every 10 to 14 weeks. Total testosterone and PSA levels were assessed at baseline and after 6, 12, 24 months of treatment. Results. The average age was 55.03 ± 2.40 years and 3 patients (7.89%) had a family history of prostate cancer. Treatment with testosterone undecanoate generated significant changes in serum total testosterone (482.29±50.78 ng/dl vs. 246.66±51.50 ng/dl, p < 0.001) but not in serum PSA levels (2.11±.0.49 ng/ml vs. 2.09±0.47 ng/ml, p - NS). Conclusion. Testosterone replacement therapy may normalize serum androgen levels but appears to have little effect on PSA levels.

Published
2012-12-15
How to Cite
Dănciulescu Miulescu, Rucsandra, Suzana Dănoiu, Denisa Margină, Sorin Păun, and Cătălina Poiana. 2012. “DYNAMICS OF PROSTATE-SPECIFIC ANTIGEN LEVELS DURING TREATMENT WITH TESTOSTERONE UNDECANOATE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 19 (4), 397-403. https://rjdnmd.org/index.php/RJDNMD/article/view/257.
Section
Original Research Articles