UPDATE ON THE MECHANISMS FACILITATING WEIGHT LOSS AND RESOLUTION OF TYPE 2 DIABETES FOLLOWING BARIATRIC SURGERY

  • Cornelia Zetu
  • Rubin Munteanu
  • Anca Frunză
  • Constantin Ionescu-Tîrgoviște
Keywords: bariatric surgery, type 2 diabetes, obesity, weight loss

Abstract

The prevalence of type 2 diabetes mellitus (T2DM) and obesity is steadily increasing worldwide. To fight the twin pandemics of obesity and T2DM, clinicians need every tool they can get. Major, durable weight loss is uncommon with medical and behavioral approaches; many diabetes drugs promote weight gain, while using them to obtain better blood glucose profiles increases the risk of hypoglycemia. Bariatric surgery seems to be the most effective method for promoting major and durable weight loss in obese subjects, leading also to ameliorations of obesity-associated co- morbidities, especially T2DM. Currently, indications for bariatric surgery include morbidly obese patients or patients with a body mass index (BMI) >35 with significant co-morbidities. Currently, bariatric surgery (also referred to as “metabolic surgery”) is advocated for the treatment of T2DM even in overweight subjects who do not meet the current BMI criteria. This review examines the current evidence regarding the mechanisms of T2DM resolution following bariatric surgery.

Published
2012-12-15
How to Cite
Zetu, Cornelia, Rubin Munteanu, Anca Frunză, and Constantin Ionescu-Tîrgoviște. 2012. “UPDATE ON THE MECHANISMS FACILITATING WEIGHT LOSS AND RESOLUTION OF TYPE 2 DIABETES FOLLOWING BARIATRIC SURGERY”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 19 (4), 425-32. https://rjdnmd.org/index.php/RJDNMD/article/view/260.
Section
Review Articles