CORRELATIONS BETWEEN PRO-INFLAMMATORY MARKERS AND GLYCATED HEMOGLOBIN IN TYPE 2 DIABETES PATIENTS
Background and Aim. Markers of inflammation are predictive of diabetic macrovascular complications. In type 2 diabetes, inflammation might be responsible for enhancing insulin resistance and may contribute to the reduction of islet cells secretory function. In the present study, we investigated the correlation between the pro-inflammatory markers and glycated hemoglobin in patients with type 2 diabetes mellitus. Materials and Methods. 66 patients (32 women and 34 men) with type 2 diabetes were recruited for this study. On fasting plasma samples C-reactive protein, interleukin-6, tumor necrosis factor-α (TNF-α) and glycated hemoglobin (HbA1c) were assayed. C-reactive protein, interleukin-6 and TNF-α were measured using enzyme-linked immunosorbent assays. The HbA1c were measured using a high-performance liquid chromatography method. Results were compared to the corresponding parameters obtained for 38 subjects (18 women and 20 men) without type 2 diabetes (control group). Results. The groups were similar in terms of age and sex but there were statistically significant differences in the recorded parameters in diabetic patients compared to the control group. Circulating levels of C-reactive protein, interleukin-6, TNF-α and HbA1c were higher (p<0.05) in patients with type 2 diabetes mellitus compared to normally metabolic patients. In the patients with type 2 diabetes mellitus HbA1c were significantly correlated with circulating C-reactive protein (r=0.909, p<0.001) and interleukin-6 (r=0.883, p<0.001) levels. Conclusion. The markers of inflammation are significantly higher in patients with type 2 diabetes compared to subjects without diabetes. The elevated markers of inflammation (C-reactive protein and interleukin-6) were significantly correlated with glycemic control (HbA1c).