HE LINK BETWEEN DIABETES, DIABETES TREATMENT AND CANCER
Diabetes mellitus (DM) and cancer are serious diseases, representing a great social burden worldwide and their association has been studied over the years. Several risk factors are common to both DM and cancer and results of epidemiological studies suggest that DM is linked to cancer incidence. However, several types of cancer (e.g. liver, pancreas, endometrial) are more frequent in type 2 DM patients while other neoplasmâ€™s (e.g. breast, colon, rectum, kidney or bladder) represent a smaller risk. Several in vivo and in vitro studies indicate that some anti-diabetic drugs, like insulin analogs, potentate tumor genesis. However, the results of the most of these studies are still under discussion. Some authors suggest that insulin therapy may increase risk for cancer, this phenomenon being mediated by IGF-1R signaling. A mild increase of cancer risk and mortality in DM (mostly type 2) patients has also been suggested. In this review we aim to summarize the current data concerning the association between DM and cancer.