MATURITY ONSET DIABETES OF THE YOUNG

  • Adrian Vlad
  • Romulus Timar
  • Diana Ivan
Keywords: monogenic diabetes, glucokinase mutations, transcription factors mutations, pregnancy

Abstract

Maturity-onset diabetes of the young (MODY), named also as “genetic defects of cell function”, is a type of diabetes mellitus determined by a single mutation of a single gene. There are nine known genes that lead to the occurrence of different subtypes of MODY, with different phenotype and prognosis. When diabetes mellitus is diagnosed during pregnancy, one has to think about the possibility that this is a MODY type (frequent determined by glucokinase mutations). The therapy ranges from diet only to diet and insulin therapy, the aim being a good glycemic control in order to prevent chronic complications. It is important to diagnose MODY because this implies a correct therapy, prognosis and genetic advice for both patient and family members.

Published
2010-12-15
How to Cite
Vlad, Adrian, Romulus Timar, and Diana Ivan. 2010. “MATURITY ONSET DIABETES OF THE YOUNG”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 17 (4), 229-37. https://rjdnmd.org/index.php/RJDNMD/article/view/354.
Section
Original Research Articles