THE IMPACT OF AN EDUCATIONAL PROGRAM IN THE MANAGEMENT OF PATIENTS WITH CHRONIC HEPATITIS C

  • Emilia Rusu
  • Gabriela Radulian
  • Florin Rusu
  • Georgiana Enache
  • Andreea Diana Dragomir
  • Alice Stoica
  • Mariana Jinga
  • Coziana Ciurtin
  • Victor Stoica
  • Dan Mircea Cheța
Keywords: hepatitis C, lifestyle change, HOMA-IR, body mass index

Abstract

Introduction: This study was designed to measure the impact of lifestyle changes, involving a diet therapy and physical exercises in patients with chronic hepatitis C (CHC). Methods: The study was conducted during January 2008 - December 2009 at ”Prof. N. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases - Bucharest, Romania. We selected 67 patients (34 men/33 women). We performed anthropometric measurements (weight, height, BMI (body mass index), bioimpedance analysis (BIA) as well as fasting serum lipids (cholesterol, triglycerides, HDL-cholesterol), glucose profile (glucose, HbA1c), liver profile (ALT, AST, GGT, alkaline phosphatase, bilirubin, albumin, total protein), blood count for all patients at baseline. Results: The average age was 53.91±10.19 years. Obesity was present in 32.8% (n=22) of patients at baseline. Total fat mass decreased with weight loss 2.21 kg (p = 0.0001) respectively 3.17 kg (p = 0.0001). Weight loss was accompanied by decreased resting energy expenditure. Triglycerides decreased from 158.11±7.63 mg/dl to 134.88±6.1 mg/dl, cholesterol decreased from 187.3±6.8 mg/dl to 168.65±4.42 mg/dl and HDL-cholesterol increased from 45.13±1.9 mg/dl to 47.2±1.39 mg/dl after 12 months. Aspartaminotransferase, alaninaminotransferese, gamma-glutamil transpeptidase decreased with significant differences. Conclusions: Patients with hepatitis C undergoing an 1-year lifestyle intervention had significant improvements in fasting glucose, fasting insulin, HOMA-IR, lipidic profile, hepatic profile and adipose tissue distribution. The present study establishes the positive impact of an educational program in the management of patients with hepatitis C.

Published
2010-12-15
How to Cite
Rusu, Emilia, Gabriela Radulian, Florin Rusu, Georgiana Enache, Andreea Dragomir, Alice Stoica, Mariana Jinga, Coziana Ciurtin, Victor Stoica, and Dan Cheța. 2010. “THE IMPACT OF AN EDUCATIONAL PROGRAM IN THE MANAGEMENT OF PATIENTS WITH CHRONIC HEPATITIS C”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 17 (4), 291-97. https://rjdnmd.org/index.php/RJDNMD/article/view/361.
Section
Original Research Articles