CARDIOVASCULAR RISK IN PATIENTS WITH TYPE 2 DIABETES AND RETHINOPATHY
Aym: Type 2 diabetes is an independent risk factor for cardiovascular disease, and also generates multiple microvascular complications. We searched the association between diabetic retinopathy (as one of the most important long time microvascular complications in diabetes) and cardiovascular risk (calculated trought UKPDS risk engine) in subjects with T2DM without known cardiovascular diseases.
Material and methods: We examined 100 patients with type 2 diabetes, without clinical evidence of coronary, cerebrovascular or peripheral artery disease; 48 (48%) were women (mean age at examination 61.23±8.49) and 52 (52%) were men (mean age 60.75±8.43). Diabetic retinopathy was graded from retinal photograph according to Early Treatment for Diabetic Retinopathy Study severity scale. The cardiovascular risk was calculated for every patient using UKPDS Risk Engine. Statistically analysis was performed using Mann-Whitney U-test, Kruskal-Wallis and Oneway Anova tests.
Results: Diabetic retinopathy was found in 59.5% men and 40.5% women. Cardiovascular risk was significantly higher in patients with retinopathy compared with patients without retinopathy (28.05±14.33 vs. 16.42±12.72 for CHD; 20.06±12.46 vs. 10.34±9.63 for fatal CHD; 13.92±10.25 vs. 9.20±8.76 for stroke; 2.24±1.86 vs. 1.39±1.47 for fatal stroke) with p=0,000... in every cases.
Conclusions: We found a statistically significant correlation between retinopathy and cardiovascular risk, which sugested that in type 2 diabetes microvascular complications are likely developping in the same time with macrovascular complications and shares the sames pathogenic ways.