RELATIONSHIPS BETWEEN SERUM EXPRESSION OF IGF-1 AND METABOLIC SYNDROME METRICS IN SYRIAN WOMEN WITH BREAST CANCER

Husseina Khaddour; Yahya Elshimali; Rucsandra Danciulescu Miulescu; Daniela Gradinaru

Husseina Khaddour Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy
Yahya Elshimali Department of Pathology and Oncology, UCLA School of Medicine & Charles R. Drew, University of Medicine and Science, USA
Rucsandra Danciulescu Miulescu Carol Davila - University of Medicine and Pharmacy; N. Paulescu - Institute of Diabetes, Metabolic and Nutrition Diseases, Bucharest, Romania
Daniela Gradinaru Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy

Keywords: Obesity, Malignancy, Metabolic dysregulation

Abstract

Background and aims: Insulin-like Growth Factors (IGF-1) plays as mediator between metabolic syndrome (MetS), oxidative stress and breast cancer (BrCa) progression. The objective of this study was to examine the relationships between IGF-1 serum levels and metabolic profile biomarkers in a population group of BrCa patients. Material and methods: 126 Syrian women with breast lesions were assigned in 3 study groups: I. Malignant breast tumor group, II. Benign breast tumor group and a Normal (control) group. The following biochemical parameters were measured: IGF-1, HDL-cholesterol, LDL-cholesterol, triglycerides (TG) and glucose. Results: The mean levels of serum IGF-1 in patients with breast cancer was significantly higher than those with benign tumors but we did not find any correlation between IGF-1 serum levels and tumor stage or lymph nodes metastases. Total cholesterol and LDL-cholesterol levels, along with TG were significantly higher in patients with BrCa versus benign and normal subjects. Conclusion: Results support the link of metabolic dysregulation and oxidative stress in BrCa progression as elevation of serum IGF-1 levels in BrCa patients are associated with metabolic syndrome markers which eventually adds more risk in cancer progression.