INTERACTION OF ADIPOKINES WITH DIABETES MELLITUS AND DENTAL IMPLANTS

Abstract

Diabetes mellitus is a chronic metabolic disease defined by the persistence of hyperglycemia leading to an inflammatory effect and a negative impact on bone formation and remodeling and impedes the osseointegration of dental implants. Dental implant surgery is a widely used procedure to replace missing teeth in patients who have diabetes. The success of an implant is dependent on osseointegration following placement. Adipokines are biologically active proteins secreted from adipose tissues, and they are considered to be involved in several functions like metabolism, immune response, inflammation. In the following article, we will describe the role of adipokines such as adiponectin, leptin, resistin, diabetes mellitus, and osseointegration of dental implants.