Mitochondrial dysfunction of mesenchymal stem cells isolated from blood with type 2 diabetic patients
The aim of the study is to focus on mitochondrial dysfunction, in the context of NASH, mitochondrial function in stem cells is likely to be impaired. Materials and methods Mesenchymal stem cell separated of peripheral blood from diabetes 2 type (DT2) patients was collected in the context of a clinical protocol authorized by the local Ethics Committee of Ukraine Association of Biobank (Ukraine), with a license from the Ministry of Health of Ukraine 04/10/2018 №1813 and 27/03/2019 №1231 by the national competent authority for biobank cord blood, cell and, tissue therapy. The study population (n = 96) was represented by diabetic patients from SI «ZIGUS NAMSU» in Kharkiv, Ukraine, and healthy volunteers. Patients were divided into two groups: group I
consisted of patients with diabetes 2 type (DT2), group II - patients with DT2 complicated course of NASH (DT2 + NASH). The control group consisted of 25 conditionally healthy persons (men and women) of the same age. Conclusion: In the modern scientific space, various directions have been proposed in the diagnosis of metabolic syndrome and the treatment of D2T.