Association of inflammatory marker, glycosylated hemoglobin, circulating lipids with microvascular complications and glycemic control of type 2 diabetes mellitus in South Indian population

  • Geetha Pandavar Sahayam Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vistas, Chennai, India
  • Shanmugasundaram Palani Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vistas, Chennai, India
Keywords: Inflammation, CRP, HbA1C, lipid profiles, microalbumniria

Abstract

Background and Aims: Inflammatory processes provoke the synthesis of various acute-phase proteins like C-reactive protein (CRP) in the liver and orchestrate a predominant role in the development of insulin resistance. Against this backdrop, the present study was undertaken to evaluate the association of inflammatory markers, glycated hemoglobin, and circulating lipids with microvascular complications in type 2 DM patients. Material and Methods: Prospective hospital-based longitudinal study was conducted with 384 patients to complete the study. The metabolic profiles were measured at baseline, 3rd month (review I), 6th month (review II), and at 12th month (review III). Lipid profiles were measured at baseline. CRP was measured at baseline, 6th month and at 12th month. Results: The recruited patients were followed for three reviews. Blood sugar level, HbA1c, and CRP were significantly decreased when compared to baseline. In this study baseline, CRP showed a positive correlation with baseline sugar levels, LDL, total cholesterol, renal parameters except for VLDL and a strong negative correlation with baseline HDL and ankle-brachial index but no significant correlation was observed with cardiac autonomic neuropathy and vibration perception threshold. Conclusion: This study concluded that due to effective pharmacotherapy the CRP level and the metabolic profiles were reduced after 12 months of follow-up.

Published
2021-10-31
How to Cite
Pandavar Sahayam, Geetha, and Shanmugasundaram Palani. 2021. “Association of Inflammatory Marker, Glycosylated Hemoglobin, Circulating Lipids With Microvascular Complications and Glycemic Control of Type 2 Diabetes Mellitus in South Indian Population”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 28 (3), 261-67. https://rjdnmd.org/index.php/RJDNMD/article/view/974.