Study to evaluate the correlation between coagulation factor, glycemic control and the severity of diabetic foot ulcers among South Indian population: A case control study

Abstract

Abstract

Background and aims: Diabetic foot ulcer (DFU) is an important complication of diabetes mellitus. It contributes to major source of morbidity and mortality among chronic diabetic patients. Aim: To find out the utility of fibrinogen, Prothrombin time (PT) and Activated Partial Thromboplastin Time (APTT) as diagnostic markers to assess the severity of Diabetic foot ulcer. Material and method: 60 subjects admitted with diabetic ulcer of foot 60 control subjects with diabetes mellitus but without DFU were included in the study. Fibrinogen, Prothrombin time(PT) and Activated Partial thromboplastin time(APTT) were measured in the samples collected from the subjects Results: The mean level of fibrinogen among cases was 452.3+/-136.4 and among cases was 306.5=/-79.6 respectively and there was statistically significant difference between the two groups.(p value=0.0001).Prothrombin time (PT) showed mean value of 16.68+/-4.2 sec among cases and 12.5+/-1.6sec among controls and the difference was statistically significant (p value=0.0001). APTT showed mean value of 36.2+/7.07sec among cases compared to 34+/-7.3sec among controls but the difference was not statistically significant (p value=0.24). Conclusions: Fibrinogen and prothrombin time levels were found to be significantly different between DFU patients and diabetic patients without DFU.